منابع مشابه
Inductive and Morphogenetic Responses of the Inner Ear to FGF Signaling
Inner ear development entails a series of sequential inductive tissue interactions where one tissue signals to direct the development of adjacent tissue[s]. Inductive signals from mesodermal, endodermal, and neuroectodermal origin control multiple aspects of early inner ear formation. Signals arising from the endoderm and mesoderm that underlie the presumptive otic field in the cephalic surface...
متن کاملFGF/FGFR-2(IIIb) signaling is essential for inner ear morphogenesis.
Interactions between FGF10 and the IIIb isoform of FGFR-2 appear to be crucial for the induction and growth of several organs, particularly those that involve budding morphogenesis. We determined their expression patterns in the inner ear and analyzed the inner ear phenotype of mice specifically deleted for the IIIb isoform of FGFR-2. FGF10 and FGFR-2(IIIb) mRNAs showed distinct, largely nonove...
متن کاملSp8 regulates inner ear development.
A forward genetic screen of N-ethyl-N-nitrosourea mutagenized Xenopus tropicalis has identified an inner ear mutant named eclipse (ecl). Mutants developed enlarged otic vesicles and various defects of otoconia development; they also showed abnormal circular and inverted swimming patterns. Positional cloning identified specificity protein 8 (sp8), which was previously found to regulate limb and ...
متن کاملFGF signaling in skeletal development.
The fibroblast growth factor receptor family consists of four receptor tyrosine kinases which bind with varying affinity and specificity to a family of at least fifteen polypeptide ligands. The receptors and ligands perform many essential functions during growth, development and repair. Recent discoveries show that a growing number of skeletal abnormalities result from mutations in the fibrobla...
متن کاملThe development of the vertebrate inner ear
The inner ear is a complex sensory organ responsible for balance and sound detection in vertebrates. It originates from a transient embryonic structure, the otic vesicle, that contains all of the information to develop autonomously into the mature inner ear. We review here the development of the otic vesicle, bringing together classical embryological experiments and recent genetic and molecular...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.176.1